A research team at Yonsei University College of Medicine said it identified the relationship between the expression level of proteins involved in the movement of substances within cells and the severity of atopic dermatitis.

A Yonsei University College of Medicine research team, led by Professors Nam Ki-teak (left) and Park Chang-wook, has found a new drug target for atopic dermatitis
A Yonsei University College of Medicine research team, led by Professors Nam Ki-teak (left) and Park Chang-wook, has found a new drug target for atopic dermatitis

The research team, led by Professors Nam Ki-teak and Park Chang-wook at the university, conducted a study to understand the effect and principle of the RAB25 protein expression level on filaggrin production.

As a result, the expression level of RAB25 protein directly affected the severity of atopic dermatitis as the team confirmed that the RAB25 protein promotes actin dynamics, which helps the process of maturation of filaggrin protein from keratohyalin granules to filaggrin and increasing skin moisturizing power.

The research team also compared and analyzed the cell protein expression level of normal skin and atopic dermatitis to reveal the effect of RAB25 protein on the skin.

The expression level of RAB25 protein in atopic dermatitis was significantly less than that of normal skin samples, which made it possible for the team to identify that the severity of atopic dermatitis increases when the RAB25 protein is deficient.

In a mouse experiment, the researchers confirmed again that when RAB25 protein is deficient, actin dynamics and the amount of filaggrin decrease, causing severe atopic dermatitis.

When oxazolone, which causes atopic dermatitis, was administered to the mice to induce skin dryness, the atopic dermatitis-affected area on mice without RAB25 protein (200 µm) was eight times wider than in normal mice (25 µm).

“By identifying that a deficiency of RAB25 protein increases the severity of atopic dermatitis and the aging principle of filaggrin, the team was able to identify the process of improving skin moisturizing ability,” professor Nam said.

The results of the research were published in Allergy.

 

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