Korean researchers said they found the clinical and immunological effects of Covid-19 in severe asthma patients.

The research team, led by Professor Lee Yong-chul and Jeong Jae-seok at the Research Center for Pulmonary Disorders of Jeonbuk National University Hospital, published the study in the online edition of Allergy.

Professors Lee Yong-chul (left) and Jeong Jae-seok of the Jeonbuk National University Hospital.
Professors Lee Yong-chul (left) and Jeong Jae-seok of the Jeonbuk National University Hospital.

The research team established the world’s first animal experimental model for severe bronchial asthma infected with Covid-19 using the state-of-the-art zoonosis institute at Jeonbuk Naional University with the veterinary college’s research team led by Uh Sung-guk.

They found that catching Covid-19 at a severe asthma state not only worsened chronic airway inflammation but also the inflammatory pathway related to Covid-19.

The researchers proved that activation of NLRP3 inflammasome, which is known as the core component of inherent immunity for severe asthma, was the major cause for negative progress on Covid-19 in asthmatic patients with severe symptoms, using transcriptome method in the experiment model.

Also, the research team re-verified the findings through a study of Covid-19 patient’s sample analysis including diverse nationals and ethnicities, in collaboration with Ewha Womans University’s research team led by Professor Kim Wan-gyu and Professor Ko Gyu-young’s research team from Korea Advanced Institute of Science and Technology (KAIST).

In addition, the research team collaborated with Professor Kim Jong-seong of medical informatics division at Jeonbuk National University College of Medicine and ultimately proved the research results through a large-scale national cohort provided by the National Health Insurance Service.

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